September 26, 2023
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How the fat-soluble nutritional vitamins A, D, and K2 work collectively to boost effectiveness and stop toxicity and why cautious supplementation is essential to make sure the correct ratios within the eating regimen.

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Over the previous few years the reputations of each vitamin A and vitamin D have obtained black eyes for his or her supposed potential toxicity, however that is largely on account of misinformation and misinterpretation.

The research have been flawed for 2 most important causes: firstly, for utilizing artificial types of these nutritional vitamins within the analysis; and secondly, for isolating them from their fat-soluble counterparts, despite the fact that they’re utterly depending on them for synergies.

We all know now that a lot of the good thing about consuming pure vitamin A and vitamin D, whether or not in meals or in complement kind, relies on their results of being taken collectively and additional, being absolutely activated by vitamin Okay2.

The Weston A. Price Foundation was the primary to determine vitamin K2 because the mysterious X-Issue proven to be so essential in synergizing with nutritional vitamins A and D in Dr. Worth’s analysis from early within the final century.

Vitamin Okay2 and Actual Vitamin A

Whenever you eat pure vitamin A in your weekly meal of liver and onions (“yeah proper!” I hear you say), liver paté, eggs, butter and ghee, every day doses of desiccated liver — all from wholesome pasture-raised animals, in fact — or from excessive vitamin cod liver oil, you’re getting numerous potential well being advantages.

By the way in which, beta carotene isn’t actual Vitamin A. Worse, consuming it in giant quantities from dietary supplements like multivitamins has been proven to be a well being threat.

In the end, you’ll be able to’t depend on beta carotene even from pure sources like carrots on your Vitamin A as a result of, even in the event you’re in good well being, you in all probability can’t convert sufficient of it into the true factor.

Consuming pure vitamin A produces particular proteins, known as matrix gla protein (MGP), in case you’re . They kind a possible clean-up crew for undesirable calcium deposits in your arteries and coronary heart valves in addition to different comfortable tissue.

In case you don’t get the deposits out of those areas, you dramatically improve your threat of coronary heart illness and different inflammation-related circumstances resembling a number of sclerosis, arthritis, and fibromyalgia. And guess what?

These proteins are going to drift round in your bloodstream utterly ineffective till they’re activated by vitamin Okay2 — then they’ll get to work and go about their cleansing duties.

In case you don’t get sufficient pure, absolutely fashioned vitamin A and unlock its potential with vitamin Okay2, you’ll be lacking out on so many advantages, together with clearing your arteries and coronary heart valves of undesirable plaque, eradicating calcium buildup from comfortable tissues to forestall irritation, correct organ formation throughout fetal improvement and psychological acuity (significantly for planning and carrying via to completion of duties).

For a while now scientists have identified that in vivo research point out that animals with excessive ranges of calcification of their arteries expertise as much as a fifty % discount in that calcification when administered vitamin Okay2.

Much more thrilling, nevertheless, is that medical trials point out that vitamin Okay2 reduces arterial stiffness in people!

Dennis Goodman, MD and famous heart specialist says in his guide Vitamin K2: The Missing Nutrient for Heart and Bone Health:

A large number of research have been performed proving Vitamin Okay2’s effectiveness in three classes: cardiovascular well being, bone well being, and kids’s well being.

Keep in mind that it’s vitamin Okay2 activating vitamin A that improves cardiovascular well being — vitamin Okay2 can’t do it alone.

Watch out as a result of an excessive amount of vitamin A in isolation (“in isolation” being the operative phrases right here — particularly if artificial as in fortified meals or most dietary supplements) could cause a vitamin D deficiency which can lead to osteoporosis.

Pure, actual vitamin A in correct proportion to vitamin D and vitamin Okay2 has by no means been proven to be dangerous in any quantity — not even to pregnant girls.

Unfavourable findings from one research identified to have been carried out on pregnant girls have been in all probability from supplementation utilizing artificial vitamin A.

Vitamin Okay2 Unlocks Vitamin D

Whenever you get sufficient vitamin D in your system, whether or not that be out of your untreated pores and skin’s publicity to direct daylight or consuming lard, fish roe, or excessive vitamin cod liver oil (model I take advantage of), it produces one other particular form of protein (this one’s known as osteocalcin).

This varieties a possible upkeep crew that guides calcium into our bones and enamel.

Once more, until there may be ample vitamin Okay2, the constructing crew stays on the sidelines and by no means will get lively strengthening your bones and enamel. In his book, Dr. Goodman says:

With out Vitamin Okay2, you’ll be able to’t ‘activate’ (activate) osteocalcin, which takes calcium the place it’s wanted — and retains it there.

In case you don’t get sufficient actual vitamin D and unlock its potential with vitamin Okay2, you’ll be lacking out on so many advantages together with correct formation of bones and enamel throughout fetal improvement and childhood, in addition to sustaining sturdy bones and enamel in adults.

Your capacity to really feel good with out turning to help from exterior substances like alcohol, sugar, hashish, and cigarettes (on account of your lack of capacity to kind your personal endorphins) can be dependent largely on getting sufficient vitamin D in your eating regimen and processing it successfully.

Watch out as a result of an excessive amount of vitamin D in isolation (“in isolation” once more being the operative phrases right here) could cause a vitamin A deficiency which can lead to coronary heart illness and different inflammation-related circumstances resembling a number of sclerosis, arthritis and fibromyalgia.

Authorities on either side of the Atlantic preserve revising their really helpful every day consumption ranges for vitamin D in an upward path as they be taught extra. And their revealed “protected most” seems to be purely arbitrary.

Synergistic Symphony

Vitamin Okay2 has two primarily helpful varieties. The primary is called short-chain menaquinones — MK-4 being a very powerful.

Quick Chain K2

MK-4 is produced by animals spending their days on pasture and changing the vitamin Okay1 contained within the lush greens they’re consuming into vitamin Okay2.

It’s unlikely that people are capable of carry out this conversion within the intestine. Whereas science continues to be unclear on this level, the best-case state of affairs is that the conversion, if it takes place in any respect, is very inefficient and positively not sufficient to completely meet organic wants.

Merchandise from pasture-fed animals resembling egg yolks, tallow, butter and ghee, goose liver pate, and doubtless schmaltz present a broader spectrum of vitamin Okay2.

In keeping with Physician of Naturopathic Drugs, Kate Rheaume-Bleue, MK-4 is unstable in your physique when you eat it and must be taken a number of occasions every day to maintain the profit.

For extra info, I like to recommend the part addressing MK-4 dietary supplements in her wonderful guide Vitamin K2 And the Calcium Paradox. How a Little Known Vitamin Could Save Your Life.

The one MK-4 dietary supplements I do know of that aren’t artificial are high-vitamin butter oil and emu oil from foraging birds.

You may as well use licensed pastured A2 ghee, which is just butter oil that has been heated. Vitamin K2 isn’t destroyed by warmth, which permits pastured ghee to function a wonderful supply of MK-4.

Lengthy Chain K2

The second helpful type of Vitamin K2 is long-chain menaquinones — MK-7 being a very powerful but additionally together with MK-8 and MK-9.

Fermented meals resembling cheeses (most testing has been carried out on gouda and brie although different aged varieties ought to have loads of it too) and natto (a specific kind of fermented soybean dish).

MK-7 is extra secure within the physique than MK-4 and can profit us all day. You may take a pure type of MK-7 dietary supplements, however it is advisable to do your due diligence to make certain.

Fermented greens, resembling home made pickles and sauerkraut, have been proven to supply a greater diversity of components of the vitamin Okay2 spectrum.

In case you’re questioning whether or not it is advisable to enhance your vitamin Okay2 consumption, within the restricted testing that has been carried out, eighty % or extra of individuals have been discovered to be poor.

So it’s a powerful wager that you just want greater than you’re getting!

In her guide, Dr. Kate Rheaume-Bleue recommends a every day consumption of 120 mcg.

However she has since revised her suggestion to about 200 mcg per day for anybody in regular well being wanting to keep up.

The dietary supplements you should purchase within the retailer appear to vary from 20 mcg to 100 mcg. For individuals with circumstances requiring therapeutic quantities, she typically recommends a lot bigger portions.

And since no research have ever discovered any quantity to trigger toxicity, there appears each cause to eat it liberally. As she says in an interview with Dr. Mercola:

We will’t at all times watch for science to determine the vitamins and check for them earlier than we go forward and profit from them.

The most effective method is acquiring as a lot K2 from the eating regimen by way of pure meals as potential with the addition of pure dietary supplements as wanted.

Keep away from any artificial choices and in addition contemplate rigorously whether or not even pure dietary supplements you discover are packaged with dangerous oils and/or GMO components.

Whereas it hasn’t filtered via to the mass media but, research on the advantages of vitamin Okay2 in relation to many well being considerations have been revealed sporadically because the Nineteen Nineties.

Epidemiological (population-based) research have proven a powerful correlation between excessive vitamin K2 consumption and discount in coronary heart illness, loss of life from coronary heart illness, liver most cancers, and prostate most cancers.

In an analogous course of to vitamin Okay2 activating the proteins generated once we eat vitamin A and vitamin D, a 3rd vitamin Okay2-dependent protein, Progress arrest-specific 6 (Gas6), appears to play an essential position in controlling whether or not cells are differentiating correctly or rising uncontrolled, which makes vitamin Okay2 probably essential in most cancers safety.

Some analysis has been revealed implicating vitamin Okay2 as a protector in opposition to prostate, lung, liver, and breast cancers by activating Gas6.

Large Meals and Large Pharma seemingly haven’t found out methods to revenue from all this but as a result of vitamin K2 is freely accessible in nature.

Dr. Rheaume-Bleue’s book seems to be the primary critical effort to deal with the daunting process of compiling the information right into a concise compendium with Dr. Goodman’s book a welcome follow-up.

Giving vitamin Okay2 its due is an concept whose time has certainly come!

food sources of fat soluble vitamins


(1) Analysis progress on the anticancer results of vitamin K2

(2) Dietary vitamin Okay consumption in relation to most cancers incidence and mortality

(3) Vitamin Okay and Most cancers

(4) The impact of menatetrenone, a vitamin K2 analog, on illness recurrence and survival in sufferers with hepatocellular carcinoma after healing therapy

(5) Dietary consumption of vitamin Okay and threat of prostate most cancers within the Heidelberg cohort of the European Potential Investigation into Most cancers and Vitamin

(6) On the Path of the Elusive X-Issue: A Sixty-Two-12 months-Outdated Thriller Lastly Solved